DIOPTRA

DIOPTRA: Early Dynamic Screening for Colorectal Cancer via Novel Protein Biomarkers Reflecting Biological Initiation Mechanisms

Description

DIOPTRA aims to introduce a front-line screening tool that will consider risk factors and protein biomarkers for pinpointing individuals at high risk for colorectal cancer (CRC) incidence. Tissue & blood samples will be examined towards a discriminative set of prognostic proteins that are detectable via standard bloodwork and can indicate a need for further evaluation (i.e. colonoscopy). Other data (e.g. medical, behavioural) will also be considered as potential risk factors. Artificial intelligence (AI) will be leveraged for assessing prognostic power, while personalised behavioural change will be promoted based on modifiable risk factors. Given the low citizen participation in CRC screening across the European Union, DIOPTRA seeks to broaden the evaluated population, boosting participation rates and bypassing age screening thresholds.

Objectives

  •  Identify a subset of protein biomarkers for early CRC screening and understand their regulatory role through protein network analysis.
  • Conduct pilot studies at clinical sites to validate the proposed protocol and refine findings using standardised prospective data.
  • Utilize state-of-the-art AI tools to detect significant biomarkers and risk factors related to CRC incidence in an objective and measurable manner.
  • Assess the effects of an extended risk factor set on CRC, offering behavioural interventions through a user-friendly mobile tool to impact modifiable pre-malignant states.
  • Advocate for change in CRC screening guidelines by providing policy makers with evidence-based data to inform decision-making on potential policy reform.
  • Investigate DIOPTRA’s expandability and network with ongoing/future cancer initiatives to empower the newly launched Knowledge Centre on Cancer, enhancing usability and accessibility for early user-friendly screening.

Consortium

1. INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS
2. TECREANDO B.V.
3. UNIVERSITY OF IOANNINA,
4. SMARTSOL SIA
5. I2GROW INNOVATION TO GROW SRL
6. NETCOMPANY-INTRASOFT SA
7. PROTATOUANS-ETAIREIA EREYNAS VIOTECHNOLOGIAS MONOPROSOPI ETAIREIA
PERIORISMENIS EYTHINIS
8. CSCY COMPUTER SOLUTIONS CYPRUS LTD
9. BLOKS ZDRAVNI I SOTSIALNI GRIZHI EOOD
10. ARTHUR’S LEGAL BV
11. CSI CENTER FOR SOCIAL INNOVATION LTD
12. CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE
13. UAB TERAGLOBUS
14. VILABS (CY) LTD
15. REGION MIDTJYLLAND
16. UNIVERZITETNI KLINICNI CENTER MARIBOR
17. KOMITEEN FOR SUNDHEDSOPLYSNING
18. FEDERATION EUROPEENNE DES HOPITAUX ET DES SOINS DE SANTE
19. D.TSAKALIDIS-G.DOMALIS OE
20. AINIGMA TECHNOLOGIES
21. FUNDACIÓN BURGOS POR LA INVESTIGACIÓN DE LA SALUD
22. ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
23. LINAC-PET SCAN OPCO LIMITED
24. GENIKO ANTIKARKINIKO OGKOLOGIKO NOSOKOMEIO ATHINON O AGIOS SAVVAS,
25. MEDIZINISCHE UNIVERSITAT GRAZ
26. MARTEL GMBH
27. SPHYNX TECHNOLOGY SOLUTIONS AG
28. CAMBRIDGE MEDICAL ACADEMY LTD

At a glance:

DIOPTRA
H2020

Project Duration:

48 Months

Project Start:

01/01/2023

Project End:

31/12/2027

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Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Education and Culture Executive Agency (EACEA). Neither the European Union nor EACEA can be held responsible for them.

Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Education and Culture Executive Agency (EACEA). Neither the European Union nor EACEA can be held responsible for them.

Funded by the Other. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Education and Culture Executive Agency (EACEA). Neither the European Union nor EACEA can be held responsible for them.

Funded by the Other. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Education and Culture Executive Agency (EACEA). Neither the European Union nor EACEA can be held responsible for them.

Funded by the Other. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Education and Culture Executive Agency (EACEA). Neither the European Union nor EACEA can be held responsible for them.

Funded by the Other. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Education and Culture Executive Agency (EACEA). Neither the European Union nor EACEA can be held responsible for them.

Funded by the Other. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Education and Culture Executive Agency (EACEA). Neither the European Union nor EACEA can be held responsible for them.

Funded by the Other. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Education and Culture Executive Agency (EACEA). Neither the European Union nor EACEA can be held responsible for them.

Funded by the Other. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Education and Culture Executive Agency (EACEA). Neither the European Union nor EACEA can be held responsible for them.

Funded by the Other. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Education and Culture Executive Agency (EACEA). Neither the European Union nor EACEA can be held responsible for them.

Funded by the Other. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Education and Culture Executive Agency (EACEA). Neither the European Union nor EACEA can be held responsible for them.

Funded by the Other. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Education and Culture Executive Agency (EACEA). Neither the European Union nor EACEA can be held responsible for them.

Funded by the Other. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Education and Culture Executive Agency (EACEA). Neither the European Union nor EACEA can be held responsible for them.

Funded by the Other. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Education and Culture Executive Agency (EACEA). Neither the European Union nor EACEA can be held responsible for them.

Funded by the Other. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Education and Culture Executive Agency (EACEA). Neither the European Union nor EACEA can be held responsible for them.

Funded by the Other. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Education and Culture Executive Agency (EACEA). Neither the European Union nor EACEA can be held responsible for them.

Funded by the Other. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Education and Culture Executive Agency (EACEA). Neither the European Union nor EACEA can be held responsible for them.

Project Number:

10056682

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